L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt

Base Information

• Chemical Name: L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt
• CAS No.: 102651-12-7
• Molecular Formula: C₇H₈O₃S*C₁₆H₂₄N₂O₃
• Molecular Weight: 464.583
• Mol file: 102651-12-7.mol

Synonyms:L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt

Chemical Property of L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt

There total 2 articles about L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

toluene-4-sulfonic acid (104-15-4) + N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide (102651-05-8) → L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt (102651-12-7)

Guidance literature:

In benzene; for 1h; Heating;

DOI:10.1021/jm00159a023

Reference yield:

Boc-Glu-OBn (30924-93-7) → L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt (102651-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / diphenylphosphorylazide, Et₂N / dimethylformamide / 45 h / 0 - 25 °C

2: 94 percent / benzene / 1 h / Heating

With diphenylphosphoranyl azide; diethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00159a023

Reference yield: 71.0%

4-amino-4-deoxy-N10-formylpteroic acid (89043-75-4) + L-glutamic acid α-benzyl ester γ-tert-butylamide p-toluenesulfonate salt (102651-12-7) → (10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts (102650-96-4)

Guidance literature:

With triethylamine; isobutyl chloroformate; In water; N,N-dimethyl-formamide; for 75h; Ambient temperature;

DOI:10.1021/jm00159a023

upstream raw materials:

toluene-4-sulfonic acid

N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-tert-butylamide

Boc-Glu-OBn

Downstream raw materials:

(10)N-formylaminopterin α-benzyl ester γ-tert-butylamide hemi p-toluenesulfonate salts

aminopterin γ-tert-butylamide

(10)N-formylaminopterin γ-tert-butylamide