tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane

Base Information

• Chemical Name: tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane
• CAS No.: 1414861-42-9
• Molecular Formula: C₃₅H₄₆O₃Si
• Molecular Weight: 542.834
• Mol file: 1414861-42-9.mol

Synonyms:tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane

Chemical Property of tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane

There total 18 articles about tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-((3R,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-1-en-3-yl)-2-methyl-6-((R,E)-pent-3-en-2-yloxy)phenol (1414861-41-8) + dimethyl sulfate (77-78-1) → tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane (1414861-42-9)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 96h; Inert atmosphere;

DOI:10.1055/s-0032-1316643

Reference yield: 95.0%

pent-3-en-2-yl (2,2,2-trichloroethyl) carbonate + 5-((3R,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-1-en-3-yl)-2-methoxy-3-methylphenol (1414861-43-0) → tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane (1414861-42-9)

Guidance literature:

With [Pd₂(dba)3]*CHCl₃; (R,R)-DACH-Ph; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1055/s-0032-1316643

Reference yield:

5-iodo-2-(methoxymethoxy)-3-methylphenol (1414861-31-6) → tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-Butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane tert-butyl[((2R,3R)-3-(4-methoxy-3-methyl-5-((R,E)-pent-3-en-2-yloxy)phenyl)-2-methylpent-4-en-1-yl)oxy]diphenylsilane (1414861-42-9)

Guidance literature:

Multi-step reaction with 12 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 19 h / 0 - 20 °C / Inert atmosphere

2.1: acetyl chloride / methanol; dichloromethane / 24 h / 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

4.1: potassium carbonate; palladium diacetate / benzene / 24 h / Inert atmosphere; Reflux

5.1: (4S,5S)-1,3-bis[(3,5-bis(trifluoromethyl)phenyl)sulfonyl]-2-bromo-4,5-diphenyl-1,3,2-diazaborolidine; triethylamine / toluene / 22 h / -78 - 20 °C / Inert atmosphere

5.2: 0.5 h / 20 °C / Inert atmosphere

6.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

7.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

8.1: 1H-imidazole; dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere

9.1: boron tribromide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

10.1: [Pd₂(dba)3]*CHCl₃; (R,R)-DACH-Ph / dichloromethane / 18 h / 20 °C / Inert atmosphere

11.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

12.1: potassium carbonate / acetone / 96 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; (4S,5S)-1,3-bis[(3,5-bis(trifluoromethyl)phenyl)sulfonyl]-2-bromo-4,5-diphenyl-1,3,2-diazaborolidine; di-isopropyl azodicarboxylate; potassium carbonate; [Pd₂(dba)3]*CHCl₃; (R,R)-DACH-Ph; water; palladium diacetate; boron tribromide; potassium carbonate; triethylamine; acetyl chloride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; benzene; 4.1: |Heck Reaction / 10.1: |Tsuji-Trost Allylation;

DOI:10.1055/s-0032-1316643

upstream raw materials:

5-iodo-2-(methoxymethoxy)-3-methylphenol

(E)-1-(but-2-en-1-yloxy)-5-iodo-2-(methoxymethoxy)-3-methylbenzene

(E)-2-(but-2-enyloxy)-4-iodo-6-methylphenol

(E)-2-(but-2-enyloxy)-4-iodo-6-methylphenyl pivalate

Downstream raw materials:

3-((3R,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-1-en-3-yl)-6-methoxy-5-methyl-2-((S,E)-pent-3-en-2-yl)phenol

3-((3R,4R)-5-((tert-Butyldiphenylsilyl)oxy)-4-methylpent-1-en-3-yl)-6-methoxy-5-methyl-2-((R,E)-pent-3-en-2-yl)phenol

5-((3R,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-1-en-3-yl)-2-methoxy-3-methylphenol