2-Methoxypyridin-3-ol

Base Information

• Chemical Name: 2-Methoxypyridin-3-ol
• CAS No.: 13472-83-8
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.127
• Hs Code.: 2933399990
• European Community (EC) Number: 816-148-1
• Mol file: 13472-83-8.mol

Synonyms:2-methoxypyridin-3-ol;13472-83-8;MFCD00457990;3-Pyridinol, 2-methoxy-;2-methoxy-3-hydroxypyridine;3-hydroxy-2-methoxy-pyridine;SCHEMBL1685043;AMY8040;RDBZAWZPZSBYDA-UHFFFAOYSA-N;AKOS003599480;AB06074;AC-33292;DS-10725;SY068872;CS-0096331;EU-0044967;EN300-128571;A910185;Z1255423921

Chemical Property of 2-Methoxypyridin-3-ol

Chemical Property:

• Melting Point: 68-69℃
• Boiling Point: 82℃
• PKA: 8.94±0.10(Predicted)
• PSA: 42.35000
• Density: 1.190±0.06 g/cm3(Predicted)
• LogP: 0.79580
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxypyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CC=N1)O

Technology Process of 2-Methoxypyridin-3-ol

There total 9 articles about 2-Methoxypyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(benzyloxy)-2-methoxypyridine → 2-methoxy-3-hydroxypyridine (13472-83-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

Reference yield: 64.0%

3-iodo-2-methoxypyridine (112197-15-6) → 2-methoxy-3-hydroxypyridine (13472-83-8)

Guidance literature:

With copper(I) oxide; water; potassium carbonate; Sucrose; at 140 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1039/d0ob01683g

Reference yield:

2-methoxypyridin-3-yl-boronic acid (163105-90-6) → 2-methoxy-3-hydroxypyridine (13472-83-8)

Guidance literature:

With Oxone; potassium phosphate; 2-(biphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In water; at 70 ℃; for 1h; chemoselective reaction;

DOI:10.1039/C6SC04014D

upstream raw materials:

2-iodo-3-hydroxypyridine

sodium methylate

3-HYDROXYPYRIDINE

2-methoxypyridin-3-yl-boronic acid

Downstream raw materials:

1-methyl-3-hydroxy-2(1H)-pyridinone

dihydroxypyridine

2,3-dimethoxy-4-hydroxypyridine

4-chloro-benzenesulfonic acid 4,6-dibromo-2-methoxy-pyridin-3-yl ester