ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

Base Information

Chemical Name:ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate
CAS No.:1094345-75-1
Molecular Formula:C₁₇H₂₅NO₅
Molecular Weight:323.389
Hs Code.:

Synonyms:ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

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Chemical Property of ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

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Technology Process of ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

There total 1 articles about ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1094345-75-1
ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 72 h / 75 °C / 3102.97 Torr / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 16.5 h / -7 - 20 °C

2.2: pH 12

3.1: caesium carbonate / 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate / toluene / 22 h / 85 °C / Inert atmosphere

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium nitrite; 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate; In water; dimethyl sulfoxide; toluene;

Reference yield:

: 1094345-75-1
ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

: 1094342-07-0
3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2.5 h / 20 °C

2.2: 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol;

Reference yield:

: 1094345-75-1
ethyl 4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinecarboxylate

: 1094342-08-1
3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-4-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2.5 h / 20 °C

2.2: 20 °C

3.1: pyridinium p-toluenesulfonate / methanol / 8 h / 60 °C

With pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; ethanol;