3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

Base Information

Chemical Name:3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile
CAS No.:1094342-07-0
Molecular Formula:C₃₀H₂₇Cl₂FN₄O₅
Molecular Weight:613.473
Hs Code.:

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

Synonyms:3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

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Chemical Property of 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

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Technology Process of 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

There total 18 articles about 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1094342-07-0
3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,3-bis-(diphenylphosphino)propane; N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 72 h / 75 °C / 3102.97 Torr / Inert atmosphere

2.1: hydrogenchloride; sodium nitrite / water / 16.5 h / -7 - 20 °C

2.2: pH 12

3.1: caesium carbonate / 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate / toluene / 22 h / 85 °C / Inert atmosphere

4.1: ethanol / 4 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2.5 h / 20 °C

5.2: 20 °C

With hydrogenchloride; 1,3-bis-(diphenylphosphino)propane; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium nitrite; 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; toluene;

Reference yield:

: 86562-71-2
2-<(S)-2,2-dimethyl-1,3-dioxolane-4-yl>-2-propanol

: 1094342-07-0
3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium p-toluenesulfonate / methanol; water / 5 h / Reflux

2.1: pyridine / 16.5 h / -10 - -5 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / acetone / 72 h / 20 °C

4.1: toluene-4-sulfonic acid; 2,2-dimethoxy-propane / toluene / 1 h / 50 °C

4.2: 2 h / 90 °C

5.1: caesium carbonate / 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate / toluene / 22 h / 85 °C / Inert atmosphere

6.1: ethanol / 4 h / Reflux

7.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2.5 h / 20 °C

7.2: 20 °C

With pyridine; pyridinium p-toluenesulfonate; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane; HATU; 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate; In tetrahydrofuran; methanol; ethanol; water; acetone; toluene;

Reference yield:

: 86562-72-3
S(-)methyl-3 butanetriol-1,2,3

: 1094342-07-0
3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 16.5 h / -10 - -5 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / acetone / 72 h / 20 °C

3.1: toluene-4-sulfonic acid; 2,2-dimethoxy-propane / toluene / 1 h / 50 °C

3.2: 2 h / 90 °C

4.1: caesium carbonate / 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate / toluene / 22 h / 85 °C / Inert atmosphere

5.1: ethanol / 4 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 2.5 h / 20 °C

6.2: 20 °C

With pyridine; caesium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane; HATU; 1,1'-binaphthalen-2-yl[bis(1,1-dimethylethyl)]phosphane; palladium diacetate; In tetrahydrofuran; ethanol; acetone; toluene;