methyl 4-bromo-2-chloronicotinate

Base Information

• Chemical Name: methyl 4-bromo-2-chloronicotinate
• CAS No.: 1064678-14-3
• Molecular Formula: C₇H₅BrClNO₂
• Molecular Weight: 250.479
• Mol file: 1064678-14-3.mol

Synonyms:methyl 4-bromo-2-chloronicotinate

Chemical Property of methyl 4-bromo-2-chloronicotinate

Chemical Property:

• Melting Point: 54-58°C
• Boiling Point: 287.4±35.0 °C(Predicted)
• PKA: -1.29±0.10(Predicted)
• Flash Point: >110℃
• Density: 1.684±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

Methyl4-Bromo-2-Chloronicotinate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: N
• Statements: 50
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-bromo-2-chloronicotinate

There total 1 articles about methyl 4-bromo-2-chloronicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-4-bromopyridine (73583-37-6) + methyl chloroformate (79-22-1) → methyl 4-bromo-2-chloronicotinate (1064678-14-3)

Guidance literature:

2-chloro-4-bromopyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -85 - -80 ℃; for 0.5h;

methyl chloroformate; In tetrahydrofuran; at -80 ℃; for 0.833333h;

DOI:10.1021/jm9002445

Reference yield: 75.0%

methyl 4-bromo-2-chloronicotinate (1064678-14-3) + tert-butyl N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate (159624-15-4) → C18H19ClN2O4

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 100 ℃; Inert atmosphere;

Reference yield: 62.0%

methyl 4-bromo-2-chloronicotinate (1064678-14-3) + dimethyl zinc(II) (544-97-8) → methyl 2-chloro-4-methylnicotinate (217811-63-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; toluene; at 70 ℃; for 8h;

DOI:10.1021/jm9002445

upstream raw materials:

2-chloro-4-bromopyridine

methyl chloroformate

Downstream raw materials:

methyl 2-chloro-4-methylnicotinate

methyl 2-chloro-4-(trifluoromethyl)nicotinate

(2-chloro-4-methyl-pyridin-3-yl)-methanol