5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

Base Information

Chemical Name:5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione
CAS No.:1433902-35-2
Molecular Formula:C₂₂H₁₉ClN₄OS
Molecular Weight:422.938
Hs Code.:

Synonyms:5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

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Chemical Property of 5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

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Technology Process of 5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

There total 7 articles about 5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 75-15-0,12122-00-8
carbon disulfide

: 1433903-59-3
6-chloro-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic acid hydrazide

: 1433902-35-2
5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

Guidance literature:: With potassium hydroxide; In ethanol; Reflux;
DOI:10.1016/j.bmcl.2016.08.071

Reference yield:

: 1433903-59-3
6-chloro-4-phenyl-2-piperidin-1-yl-quinoline-3-carboxylic acid hydrazide

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 1433902-35-2
5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

Guidance literature:: With triethylamine; In tetrahydrofuran; at 50 ℃; for 72h;

Reference yield:

: 284663-87-2
6-chloro-2-oxo-4-phenyl-1,2-dihydro-quinoline-3-carboxylic acid methyl ester

: 1433902-35-2
5-(6-chloro-4-phenyl-2-piperidin-1-yl-quinolin-3-yl)-3H-[1,3,4]oxadiazole-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / ethanol / 72 h / 50 °C / Sealed tube

2.1: trichlorophosphate / 3 h / 120 °C

2.2: 4 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.33 h / 120 °C / Microwave irradiation

4.1: triethylamine / tetrahydrofuran / 72 h / 50 °C

With triethylamine; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;