N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

Base Information

Chemical Name:N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine
CAS No.:1415791-38-6
Molecular Formula:C₂₃H₂₆F₂N₆O
Molecular Weight:440.496
Hs Code.:

Synonyms:N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

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Chemical Property of N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

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Technology Process of N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

There total 17 articles about N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415794-42-1
tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

: 1415791-38-6
N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

Guidance literature:: tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate; With hydrogenchloride; In ethyl acetate; at 20 ℃;

With ammonium hydroxide; In dichloromethane;

Reference yield:

: 1415793-79-1
tert-butyl 3-(((7-chloropyrido[4,3-b]pyrazin-5-yl)amino)methyl)-5-hydroxypiperidine-1-carboxylate

: 1415791-38-6
N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C

3: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.33 h / 160 °C / microwave irradiation; Sealed tube

4: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; caesium carbonate; Dess-Martin periodane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;

Reference yield:

: 1415794-67-0
tert-butyl 3-(((7-chloropyrido[4,3-b]pyrazin-5-yl)amino)methyl)-5-oxopiperidine-1-carboxylate

: 1415791-38-6
N-((5,5-difluoropiperidin-3-yl)methyl)-7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C

2: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.33 h / 160 °C / microwave irradiation; Sealed tube

3: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;