tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate
CAS No.:1415794-42-1
Molecular Formula:C₂₈H₃₄F₂N₆O₃
Molecular Weight:540.613
Hs Code.:

Synonyms:tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

There total 15 articles about tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400589-67-4
1,1-dimethylethyl 5-{[(7-chloropyrido[3,4-b]pyrazin-5-yl)amino]methyl}-3,3-difluoro-1-piperidinecarboxylate

: 186498-02-2
4-(4-morpholinyl)phenylboronic acid

: 1415794-42-1
tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,2-dimethoxyethane; water; at 160 ℃; for 1.33333h; microwave irradiation; Sealed tube;

Reference yield:

: 1415794-67-0
tert-butyl 3-(((7-chloropyrido[4,3-b]pyrazin-5-yl)amino)methyl)-5-oxopiperidine-1-carboxylate

: 1415794-42-1
tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C

2: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.33 h / 160 °C / microwave irradiation; Sealed tube

With diethylamino-sulfur trifluoride; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1415793-79-1
tert-butyl 3-(((7-chloropyrido[4,3-b]pyrazin-5-yl)amino)methyl)-5-hydroxypiperidine-1-carboxylate

: 1415794-42-1
tert-butyl 3,3-difluoro-5-((7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Dess-Martin periodane / dichloromethane / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 20 °C

3: caesium carbonate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1.33 h / 160 °C / microwave irradiation; Sealed tube

With diethylamino-sulfur trifluoride; caesium carbonate; Dess-Martin periodane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,2-dimethoxyethane; dichloromethane; water;