{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

Base Information

Chemical Name:{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene
CAS No.:208659-01-2
Molecular Formula:C₂₇H₄₈O₃Si₂
Molecular Weight:476.847
Hs Code.:

Synonyms:{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

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Chemical Property of {2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

Chemical Property:

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Technology Process of {2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

There total 16 articles about {2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 208659-00-1
(1R,5R)-3-[2-Benzyloxy-eth-(Z)-ylidene]-5-(tert-butyl-dimethyl-silanyloxy)-cyclohexanol

: 208659-01-2
{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

Guidance literature:: DOI:10.1016/S0040-4039(98)00682-0

Reference yield:

: 58558-53-5
(((3-methylbut-3-en-1-yl)oxy)methyl)benzene

: 208659-01-2
{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

Guidance literature:: Multi-step reaction with 8 steps

1: 67 percent / EtAlCl₂ / CH₂Cl₂ / Ambient temperature

2: 98 percent / DIBAL-H / toluene / -78 °C

3: 58 percent / (-)-DET/Ti(Oi-Pr)4, TBHP, 4 Angstroem molecular sieves / CH₂Cl₂ / -20 °C

4: 1.) Red-Al; 2.) PPTS / 1.) MeOH, THF, r.t.; 2.) CH₂Cl₂, r.t.

5: DIBAL-H / CH₂Cl₂ / 0 - 20 °C

6: 65 percent / (R)-binaphthol/Cl₂Ti(Oi-Pr)2, 4 Angstroem molecular sieves / CH₂Cl₂ / 38 h / Ambient temperature

7: 89 percent / CAN / acetonitrile; H₂O / Ambient temperature

8: imidazole / dimethylformamide / Ambient temperature

With (R)-binaphthol; 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; titanium(IV) dichlorodiisopropylate; ammonium cerium(IV) nitrate; 4 A molecular sieve; ethylaluminum dichloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; (-)-diethyl tartrate; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4039(98)00272-X

Reference yield:

: 208658-85-9
(2R,3R)-5-[2-(benzyloxy)ethyl]-2,3-epoxy-5-en-1-hexanol

: 208659-01-2
{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Red-Al; 2.) PPTS / 1.) MeOH, THF, r.t.; 2.) CH₂Cl₂, r.t.

2: DIBAL-H / CH₂Cl₂ / 0 - 20 °C

3: 65 percent / (R)-binaphthol/Cl₂Ti(Oi-Pr)2, 4 Angstroem molecular sieves / CH₂Cl₂ / 38 h / Ambient temperature

4: 89 percent / CAN / acetonitrile; H₂O / Ambient temperature

5: imidazole / dimethylformamide / Ambient temperature

With (R)-binaphthol; 1H-imidazole; titanium(IV) dichlorodiisopropylate; ammonium cerium(IV) nitrate; 4 A molecular sieve; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(98)00272-X