2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol

Base Information

• Chemical Name: 2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol
• CAS No.: 139356-37-9
• Molecular Formula: C20H42O3Si2
• Molecular Weight: 386.723
• DSSTox Substance ID: DTXSID101133899
• Nikkaji Number: J965.140C
• Mol file: 139356-37-9.mol

Synonyms:139356-37-9;2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol;2-((3R,5R)-3,5-Bis((tert-butyldimethylsilyl)oxy)cyclohexylidene)ethanol;2-[(3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]cyclohexylidene]ethanol;Paricalcitol Impurity B001;SCHEMBL6655447;2-((3R,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)cyclohexylidene) ethanol;YDSSQNPZARKZPC-QZTJIDSGSA-N;DTXSID101133899;CS-M1241;CS-13839;2-[3beta,5alpha-Bis(tert-butyldimethylsilyloxy)cyclohexylidene]ethanol;2-[(3R,5R)-3,5-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]cyclohexylidene]ethanol

Chemical Property of 2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol

Chemical Property:

• PSA: 38.69000
• LogP: 5.86980
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 386.26724827
• Heavy Atom Count: 25
• Complexity: 432

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OC1CC(CC(=CCO)C1)O[Si](C)(C)C(C)(C)C
• Isomeric SMILES: CC(C)(C)[Si](C)(C)O[C@H]1C[C@@H](CC(=CCO)C1)O[Si](C)(C)C(C)(C)C

Technology Process of 2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol

There total 42 articles about 2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene (208659-01-2) → [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol (139356-37-9)

Guidance literature:

With 4,4'-di(tert-butyl)-[1,1-biphenyl]yllithium;

DOI:10.1016/S0040-4039(98)00682-0

Reference yield: 90.0%

2-[(3'R,5'R)-3',5'-bis[(tert-butyldimethylsilyl)oxy]cyclohexylidene]acetic acid methyl ester → [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol (139356-37-9)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield: 23.36%

tert-butyldimethylsilyl chloride (18162-48-6) + ethyl ((3R,5R)-3,5-diacetoxy-cyclohexylidene)-acetate (332097-70-8) → [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol (139356-37-9)

Guidance literature:

ethyl ((3R,5R)-3,5-diacetoxy-cyclohexylidene)-acetate; With potassium carbonate; In water; at 22 ℃; for 6h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 22 ℃; for 3h;

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -15 ℃; for 1.5h;

DOI:10.1016/S0040-4020(00)01035-8

upstream raw materials:

[(3R,5R)-3,5-bis-(tert-butyldimethylsilyloxy)cyclohexylidene]acetic acid ethyl ester

{2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-ethoxymethyl}-benzene

tert-butyldimethylsilyl chloride

ethyl ((3R,5R)-3,5-diacetoxy-cyclohexylidene)-acetate

Downstream raw materials:

1α,25-dihydroxy-19-nor-vitamin D₃

(1R,7aR)-4-[2-[(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-cyclohexylidene]-eth-(E)-ylidene]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-indene

C₄₅H₇₈O₆SSi₂

C₃₉H₇₂O₃Si₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 139356-37-9 2-((3R,5R)-3,5-bis(tert-butyldiMethylsilyloxy)cyclohexylidene)ethanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send