methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Base Information

Chemical Name:methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate
CAS No.:1087352-87-1
Molecular Formula:C₁₉H₁₈FN₅O₄S
Molecular Weight:431.447
Hs Code.:

Synonyms:methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

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Chemical Property of methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

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Technology Process of methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

There total 9 articles about methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1087352-59-7
tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

: 79-22-1
methyl chloroformate

: 1087352-87-1
methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Guidance literature:: tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

methyl chloroformate; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 324789-64-2
2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

: 1087352-87-1
methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 3 h / 60 °C

3.2: 2 h / 0 - 20 °C

4.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

4.2: 5 h / 90 °C / Heating / reflux

5.1: triethylamine / tetrahydrofuran; methanol / 0 - 20 °C

6.1: Lawessons reagent / 1,4-dioxane / 1 h / 60 °C

7.1: toluene / 2 h / 110 °C / Heating / reflux

8.1: potassium carbonate / acetonitrile / 4 h / 75 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

9.2: 1 h / 0 - 20 °C

With Lawessons reagent; thionyl chloride; sodium azide; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 324789-22-2
4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid

: 1087352-87-1
methyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / dichloromethane / 3 h / 60 °C

1.2: 2 h / 0 - 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2.2: 5 h / 90 °C / Heating / reflux

3.1: triethylamine / tetrahydrofuran; methanol / 0 - 20 °C

4.1: Lawessons reagent / 1,4-dioxane / 1 h / 60 °C

5.1: toluene / 2 h / 110 °C / Heating / reflux

6.1: potassium carbonate / acetonitrile / 4 h / 75 °C

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

7.2: 1 h / 0 - 20 °C

With Lawessons reagent; thionyl chloride; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;