tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Base Information

Chemical Name:tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate
CAS No.:1087352-59-7
Molecular Formula:C₂₂H₂₄FN₅O₄S
Molecular Weight:473.528
Hs Code.:

Synonyms:tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

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Chemical Property of tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

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Technology Process of tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

There total 9 articles about tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 288-32-4
1H-imidazole

: 1087353-76-1
tert-butyl {3-[4-(4-chloromethyl-thiazol-2-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

: 1087352-59-7
tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Guidance literature:: With potassium carbonate; In acetonitrile; at 75 ℃; for 4h;

Reference yield:

: 324789-22-2
4-(5(R)-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluorobenzoic acid

: 1087352-59-7
tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane / 3 h / 60 °C

1.2: 2 h / 0 - 20 °C

2.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2.2: 5 h / 90 °C / Heating / reflux

3.1: triethylamine / tetrahydrofuran; methanol / 0 - 20 °C

4.1: Lawessons reagent / 1,4-dioxane / 1 h / 60 °C

5.1: toluene / 2 h / 110 °C / Heating / reflux

6.1: potassium carbonate / acetonitrile / 4 h / 75 °C

With Lawessons reagent; thionyl chloride; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 324789-28-8
5-(S)-aminomethyl-3-[4'-aminocarbonyl-3'-fluorophenyl]oxazolidine-2-one

: 1087352-59-7
tert-butyl {3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran; methanol / 0 - 20 °C

2: Lawessons reagent / 1,4-dioxane / 1 h / 60 °C

3: toluene / 2 h / 110 °C / Heating / reflux

4: potassium carbonate / acetonitrile / 4 h / 75 °C

With Lawessons reagent; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; acetonitrile;