tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

Base Information

Chemical Name:tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate
CAS No.:951744-22-2
Molecular Formula:C₃₆H₄₁NO₈
Molecular Weight:615.723
Hs Code.:

Synonyms:tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

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Chemical Property of tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

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Technology Process of tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

There total 6 articles about tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 863643-32-7
tert-Butyl 3-(1-benzyloxycarbonyl-4-piperidyl)-3-oxopropionate

: 27895-95-0
2-bromo-1,2-bis(4-methoxyphenyl)ethanone

: 951744-22-2
tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield:

: 498-94-2
isonipecotic acid

: 951744-22-2
tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water / 20 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

3.2: 1.5 h / -78 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C

With n-butyllithium; oxalyl dichloride; sodium hydrogencarbonate; potassium carbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 10314-98-4
1-benzyloxycarbonylpiperidine-4-carboxylic acid

: 951744-22-2
tert-butyl 2-(1-benzyloxycarbonyl-4-piperidinecarbonyl)-3,4-bis(4-methoxyphenyl)-4-oxobutyrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.5 - 2 h / 0 - 20 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: 1.5 h / -78 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 20 °C

With n-butyllithium; oxalyl dichloride; potassium carbonate; diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;