4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

Base Information

Chemical Name:4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol
CAS No.:184221-16-7
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

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Chemical Property of 4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

Chemical Property:

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Technology Process of 4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

There total 14 articles about 4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 184221-15-6
4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butyric acid

: 184221-16-7
4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.25h; Heating;
DOI:10.1021/ja962757p

Reference yield:

: 64304-83-2
trans-1-(4-methoxyphenyl)-2-methoxyethene

: 184221-16-7
4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 99 percent / Yb(fod)3 / 1,2-dichloro-ethane / 7 h / Heating

2: 99 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.17 h / -78 °C

3: 85 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 59 percent / NH₂OH*HCl / acetonitrile / 1.5 h / Heating

5: 94 percent / 1percent aq. NaOH / methanol / 1.5 h / Ambient temperature

6: 91 percent / SOCl₂, pyridine / benzene / 0.33 h / Heating

7: 77 percent / t-BuOK / tetrahydrofuran / 0.17 h / Heating

8: 88 percent / t-BuOK / dimethylsulfoxide / 0.08 h

9: 99 percent / aq. HCl / dioxane / 48 h / 40 °C

10: 89 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)ytterbium; hydroxylamine hydrochloride; potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; acetonitrile; benzene;
DOI:10.1021/ja962757p

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 184221-16-7
4-[4-(3,4-Dimethoxy-phenyl)-5-(4-methoxy-phenyl)-pyridin-2-yl]-butan-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1: 71 percent / tetrahydrofuran / 12 h / Heating

2: 99 percent / Yb(fod)3 / 1,2-dichloro-ethane / 7 h / Heating

3: 99 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / 0.17 h / -78 °C

4: 85 percent / pyridine / CH₂Cl₂ / 0.5 h / Ambient temperature

5: 59 percent / NH₂OH*HCl / acetonitrile / 1.5 h / Heating

6: 94 percent / 1percent aq. NaOH / methanol / 1.5 h / Ambient temperature

7: 91 percent / SOCl₂, pyridine / benzene / 0.33 h / Heating

8: 77 percent / t-BuOK / tetrahydrofuran / 0.17 h / Heating

9: 88 percent / t-BuOK / dimethylsulfoxide / 0.08 h

10: 99 percent / aq. HCl / dioxane / 48 h / 40 °C

11: 89 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / Heating

With pyridine; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)ytterbium; hydroxylamine hydrochloride; potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; acetonitrile; benzene;
DOI:10.1021/ja962757p