ethyl 6-bromo-2-chloro-3-fluorobenzoate

Base Information

• Chemical Name: ethyl 6-bromo-2-chloro-3-fluorobenzoate
• CAS No.: 1610927-38-2
• Molecular Formula: C₉H₇BrClFO₂
• Molecular Weight: 281.509
• Mol file: 1610927-38-2.mol

Synonyms:ethyl 6-bromo-2-chloro-3-fluorobenzoate

Chemical Property of ethyl 6-bromo-2-chloro-3-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 6-bromo-2-chloro-3-fluorobenzoate

There total 1 articles about ethyl 6-bromo-2-chloro-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

ethyl 2-bromo-5-fluorobenzoate (139911-28-7) → ethyl 6-bromo-2-chloro-3-fluorobenzoate (1610927-38-2)

Guidance literature:

With sodium persulfate; N-chloro-succinimide; trifluorormethanesulfonic acid; palladium diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 4h; regioselective reaction;

DOI:10.1016/j.cclet.2014.03.021

Reference yield: 90.0%

ethyl 6-bromo-2-chloro-3-fluorobenzoate (1610927-38-2) → ethyl 6-amino-2-chloro-3-fluorobenzoate (153500-76-6)

Guidance literature:

With copper(I) oxide; ammonium hydroxide; In water; at 80 ℃; for 12h; Sealed tube;

DOI:10.1016/j.cclet.2014.03.021

Reference yield:

ethyl 6-bromo-2-chloro-3-fluorobenzoate (1610927-38-2) → (6-amino-2-chloro-3-fluorophenyl)methanol (1347720-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(I) oxide; ammonium hydroxide / water / 12 h / 80 °C / Sealed tube

2: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 - 20 °C

With copper(I) oxide; ammonium hydroxide; lithium aluminium tetrahydride; In tetrahydrofuran; water;

DOI:10.1016/j.cclet.2014.03.021

upstream raw materials:

ethyl 2-bromo-5-fluorobenzoate

Downstream raw materials:

ethyl 6-amino-2-chloro-3-fluorobenzoate

(6-amino-2-chloro-3-fluorophenyl)methanol

Refernces