Ethyl 2-bromo-5-fluorobenzoate

Base Information

• Chemical Name: Ethyl 2-bromo-5-fluorobenzoate
• CAS No.: 139911-28-7
• Molecular Formula: C9H8BrFO2
• Molecular Weight: 247.064
• Hs Code.: 2916399090
• Mol file: 139911-28-7.mol

Synonyms:ethyl 2-bromo-5-fluoro-benzoate;

Chemical Property of Ethyl 2-bromo-5-fluorobenzoate

Chemical Property:

• Vapor Pressure: 0.01mmHg at 25°C
• Boiling Point: 264.637oC at 760 mmHg
• Flash Point: 113.849oC
• PSA: 26.30000
• Density: 1.504g/cm3
• LogP: 2.76490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.00% ^*data from raw suppliers

Ethyl2-Bromo-5-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2-bromo-5-fluorobenzoate

There total 3 articles about Ethyl 2-bromo-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethanol (64-17-5) + 2-Bromo-5-fluorobenzoic acid (394-28-5) → ethyl 2-bromo-5-fluorobenzoate (139911-28-7)

Guidance literature:

With sulfuric acid; at 100 ℃; for 12h; Sealed tube;

DOI:10.1021/jacs.7b04490

Reference yield: 70.0%

ethyl 3-fluorobenzoate (451-02-5) → ethyl 2-bromo-5-fluorobenzoate (139911-28-7)

Guidance literature:

With sodium persulfate; N-Bromosuccinimide; trifluorormethanesulfonic acid; palladium diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 9h;

DOI:10.1016/j.cclet.2014.03.021

Reference yield: 34.0%

→ ethyl 2-bromo-5-fluorobenzoate (139911-28-7)

Guidance literature:

upstream raw materials:

ethyl 3-fluorobenzoate

ethanol

2-Bromo-5-fluorobenzoic acid

Downstream raw materials:

ethyl 6-bromo-2-chloro-3-fluorobenzoate

ethyl 6-amino-2-chloro-3-fluorobenzoate

(6-amino-2-chloro-3-fluorophenyl)methanol

ethyl 2-cyano-5-fluorobenzoate

Refernces

• 1、 Sun, Xiu-Yun,Sun, Yong-Hui,Rao, Yu. "A gram-scale synthesis of multi-substituted arenes via palladium catalyzed C-H halogenation". . p. 667 - 669. Retrieved 2014/06/09.