(2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

Base Information

Chemical Name:(2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide
CAS No.:1613396-51-2
Molecular Formula:C₂₀H₂₂ClF₃N₆O₂
Molecular Weight:470.882
Hs Code.:

Synonyms:(2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

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Chemical Property of (2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

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Technology Process of (2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

There total 10 articles about (2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1613396-41-0
(3S)-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]tetrahydrofuran-2-one

: 1503894-95-8
1-(4-chlorophenyl)-5-isopropyl-tiazol-4-amine

: 1613396-51-2
(2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

Guidance literature:: With trimethylaluminum; In 1,2-dichloro-ethane; toluene; at 0 - 20 ℃;

Reference yield:

: C₁₈H₂₁F₃N₂O₃

: 1613396-51-2
(2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1,4-dioxane / 1 h / 80 °C

2: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0 - 20 °C

With sulfuric acid; trimethylaluminum; In 1,4-dioxane; 1,2-dichloro-ethane; toluene;

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 1613396-51-2
(2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / methanol; tert-butyl methyl ether / 0 - 20 °C / 1520.1 Torr

2.1: sodium hydroxide / methanol / 1 h / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1.08 h / 0 - 20 °C

4.1: sodium azide / acetone; water / 0.5 h / 0 - 20 °C

5.1: toluene / 1.5 h / 100 °C

5.2: 1 h / 20 - 100 °C

6.1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 0 - 20 °C

With sodium azide; oxalyl dichloride; trimethylaluminum; sodium methylate; sodium hydroxide; In methanol; dichloromethane; tert-butyl methyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene;