(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

Base Information

Chemical Name:(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
CAS No.:1312302-16-1
Molecular Formula:C₆₂H₇₈N₆O₁₁
Molecular Weight:1083.33
Hs Code.:

(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

Synonyms:(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

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Chemical Property of (2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

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Technology Process of (2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

There total 6 articles about (2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1225383-32-3
C₂₅H₃₂N₂O₅

: (9H-fluoren-9-yl)methyl (2R,3S)-4-((S)-1-{2-[2-(2-aminoethoxy)ethoxy]ethylamino}-4-methyl-1-oxopentan-2-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylcarbamate hydrochloride

: 1312302-16-1
(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 5h; Cooling with ice;
DOI:10.1016/j.bmc.2011.03.057

Reference yield:

: 1312302-12-7
(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

: 1312302-16-1
(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Cooling with ice

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/j.bmc.2011.03.057

Reference yield:

: 206265-94-3
2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl 4-methylbenzenesulfonate

: 1312302-16-1
(2E,4E,6E,8E)-2-cyanoethyl 9-((E)-3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethylamino]-2-oxoethoxyimino}-2,6,6-trimethylcyclohex-1-enyl)-3,7-dimethylnona-2,4,6,8-tetraenoate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C / Cooling with ice

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Cooling with ice

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

With hydrogenchloride; sodium azide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.057