(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Base Information

Chemical Name:(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid
CAS No.:1310451-45-6
Molecular Formula:C₄₄H₆₅N₅O₉
Molecular Weight:808.028
Hs Code.:

(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Synonyms:(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

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Chemical Property of (2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

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Technology Process of (2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

There total 8 articles about (2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312302-18-3
C₅₉H₇₅N₅O₁₁

: 1310451-45-6
(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-dodecylthiol; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2011.03.057

Reference yield:

: 950683-55-3
{2-[2-(2-azidoethoxy)ethoxy]ethyl}carbamic acid tert-butyl ester

: 1310451-45-6
(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C / Cooling with ice

3: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Cooling with ice

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

5: methanol; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-dodecylthiol / dichloromethane / 1 h / 20 °C

With hydrogenchloride; methanol; palladium 10% on activated carbon; tetrabutyl ammonium fluoride; hydrogen; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; 1-dodecylthiol; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.057

Reference yield:

: (9H-fluoren-9-yl)methyl (2R,3S)-4-((S)-1-{2-[2-(2-aminoethoxy)ethoxy]ethylamino}-4-methyl-1-oxopentan-2-ylamino)-3-hydroxy-4-oxo-1-phenylbutan-2-ylcarbamate hydrochloride

: 1310451-45-6
(2E,4E,6E,8E)-9-[(E)-3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethylamino}-2-oxoethoxyimino)-2,6,6-trimethylcyclohex-1-enyl]-3,7-dimethylnona-2,4,6,8-tetraenoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran / 5 h / 20 °C / Cooling with ice

2: methanol; tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-dodecylthiol / dichloromethane / 1 h / 20 °C

With methanol; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 1-dodecylthiol; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2011.03.057