(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

Base Information

Chemical Name:(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide
CAS No.:1312302-12-7
Molecular Formula:C₄₂H₅₆N₄O₉
Molecular Weight:760.928
Hs Code.:

(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

Synonyms:(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

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Chemical Property of (S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

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Technology Process of (S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

There total 4 articles about (S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1225383-33-4
(S)-2-{(2S,3R)-3-[(9H-fluoren-9-yl)methoxy]carbonylamino-2-hydroxy-4-phenylbutanamido}-4-methylpentanoic acid

: 153086-78-3
tert-butyl {2-[2-(2-aminoethoxy)ethoxy]ethyl}carbamate

: 1312302-12-7
(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 22h; Cooling with ice;
DOI:10.1016/j.bmc.2011.03.057

Reference yield:

: 206265-94-3
2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecane-13-yl 4-methylbenzenesulfonate

: 1312302-12-7
(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 8 h / 60 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C / Cooling with ice

With sodium azide; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.057

Reference yield:

: 950683-55-3
{2-[2-(2-azidoethoxy)ethoxy]ethyl}carbamic acid tert-butyl ester

: 1312302-12-7
(S)-2-{2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy}ethyl 2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenyl-butanamido)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 13 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 22 h / 20 °C / Cooling with ice

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.057