N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

Base Information

Chemical Name:N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide
CAS No.:135714-87-3
Molecular Formula:C₂₆H₂₅NO₄
Molecular Weight:415.489
Hs Code.:

Synonyms:N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

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Chemical Property of N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

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Technology Process of N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

There total 7 articles about N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91-16-7
1,2-dimethoxybenzene

: 135714-87-3
N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1) 98percent H₂SO₄, gl. acetic acid / 1) 70 deg C, 1.5 h, 2) reflux, overnight

2: 1) EtONa, 2) hexamethylphosphoramide / 1) THF, 0.5 h, 2) THF, rt, overnight

3: 73 percent / NaOH / ethanol; H₂O / Heating

4: 60 percent / polyphosphoric acid / 6 h / Ambient temperature

5: 96 percent / NaOH / ethanol; H₂O / Heating

6: 1) Et₃N, 2-chloro-N-methylpyridinium iodide / 1) acetonitrile, 0.5 h, 2) 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; PPA; sulfuric acid; 2-chloro-1-methyl-pyridinium iodide; sodium ethanolate; acetic acid; triethylamine; In ethanol; water;

Reference yield:

: 2897-71-4
ethyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxylate

: 135714-87-3
N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaOH / ethanol; H₂O / Heating

2: 1) Et₃N, 2-chloro-N-methylpyridinium iodide / 1) acetonitrile, 0.5 h, 2) 0.5 h

With sodium hydroxide; 2-chloro-1-methyl-pyridinium iodide; triethylamine; In ethanol; water;

Reference yield:

: 97611-71-7
ethyl α-phenyl-3,4-dimethoxyphenylacetate

: 135714-87-3
N-benzyl 1,2,3,4-tetrahydro-6,7-dimethoxy-4-oxo-1-phenylnaphthalene-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1) EtONa, 2) hexamethylphosphoramide / 1) THF, 0.5 h, 2) THF, rt, overnight

2: 73 percent / NaOH / ethanol; H₂O / Heating

3: 60 percent / polyphosphoric acid / 6 h / Ambient temperature

4: 96 percent / NaOH / ethanol; H₂O / Heating

5: 1) Et₃N, 2-chloro-N-methylpyridinium iodide / 1) acetonitrile, 0.5 h, 2) 0.5 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; PPA; 2-chloro-1-methyl-pyridinium iodide; sodium ethanolate; triethylamine; In ethanol; water;