4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

Base Information

Chemical Name:4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid
CAS No.:1428526-17-3
Molecular Formula:C₂₄H₂₁N₄O₅P
Molecular Weight:476.428
Hs Code.:

Synonyms:4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

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Chemical Property of 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

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Technology Process of 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

There total 3 articles about 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 4-(amino(4-methoxyphenyl)methyl)phenylphosphinic acid hydrochloride

: 56406-45-2
4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid

: 1428526-17-3
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

Guidance literature:: 4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid; With triethylamine; In acetonitrile; at 20 ℃; for 0.25h;

With 1,1'-carbonyldiimidazole; In acetonitrile; at 70 ℃; for 3h;

4-(amino(4-methoxyphenyl)methyl)phenylphosphinic acid hydrochloride; In acetonitrile; at 70 ℃; for 2h;

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 1428526-17-3
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 24 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium methylate / methanol / Reflux

3.1: triethylamine / acetonitrile / 0.25 h / 20 °C

3.2: 3 h / 70 °C

3.3: 2 h / 70 °C

With sodium methylate; triethylamine; In methanol; acetonitrile;

Reference yield:

: 51285-26-8,61097-49-2
pyridine-2-carboxamidine hydrochloride

: 1428526-17-3
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(4-methoxyphenyl)methyl)phenylphosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / Reflux

2.1: triethylamine / acetonitrile / 0.25 h / 20 °C

2.2: 3 h / 70 °C

2.3: 2 h / 70 °C

With sodium methylate; triethylamine; In methanol; acetonitrile;