6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole

Base Information

• Chemical Name: 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole
• CAS No.: 1219925-73-1
• Molecular Formula: C₂₇H₃₅N₃O₃
• Molecular Weight: 449.593

Synonyms:6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole

Chemical Property of 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole

Chemical Property:

• Boiling Point: 587.7±50.0 °C(Predicted)
• Density: 1.151±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

E6446 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole

There total 6 articles about 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

pyrrolidine (123-75-1) + 6-(3-chloropropoxy)-2-(4-(3-chloropropoxy)phenyl)benzo[d]oxazole (1219925-75-3) → 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole (1219925-73-1)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 8h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.03.086

Reference yield:

4-methoxybenzoic acid (100-09-4) → 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole (1219925-73-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.5 h / 0 - 20 °C

3.1: acetic acid / 48 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 8 h / 110 °C / Sealed tube; Inert atmosphere

With boron tribromide; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.ejmech.2017.03.086

Reference yield:

2,4-Dimethoxyaniline (2735-04-8,161687-55-4) → 6-[3-(pyrrolidin-1-yl)propoxy]-2-{4-[3-(pyrrolidin-1-yl)propoxy]phenyl}-1,3-benzoxazole (1219925-73-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 0.5 h / 0 - 20 °C

3.1: acetic acid / 48 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 8 h / 110 °C / Sealed tube; Inert atmosphere

With boron tribromide; potassium carbonate; acetic acid; 1,1'-carbonyldiimidazole; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.ejmech.2017.03.086

upstream raw materials:

pyrrolidine

6-(3-chloropropoxy)-2-(4-(3-chloropropoxy)phenyl)benzo[d]oxazole

4-methoxybenzoic acid

2,4-Dimethoxyaniline

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