5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

Base Information

Chemical Name:5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt
CAS No.:1198744-80-7
Molecular Formula:C₂₀H₂₁N₂O₄*Na
Molecular Weight:376.388
Hs Code.:

Synonyms:5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

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Chemical Property of 5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

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Technology Process of 5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

There total 12 articles about 5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₂N₂O₄*(x)ClH

: 1198744-80-7
5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

Guidance literature:: With sodium hydroxide; In water;

Reference yield:

: 540-38-5
p-Iodophenol

: 1198744-80-7
5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

Guidance literature:: Multi-step reaction with 9 steps

1.1: copper(I) oxide / N,N-dimethyl-formamide / 15 h / 110 °C

2.1: potassium carbonate / acetone / 4 h / 65 °C

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 20 °C

3.2: pH 2 - 3

4.1: triethylamine / tetrahydrofuran / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.5 h / 20 °C

7.1: Chiral Pack AD-H column / Resolution of racemate

8.1: hydrogenchloride / methanol / 2 h / 20 °C

9.1: sodium hydroxide / water

With copper(I) oxide; hydrogenchloride; hydroxylamine hydrochloride; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; toluene; 6.1: Mitsunobu reaction;

Reference yield:

: 1030828-96-6
5-[4-(benzyloxy)phenyl]-1,2-oxazol-3-ol

: 1198744-80-7
5-(4-(((1S)-1-methyl-2-(2-((1-methylethyl)oxy)pyridin-4-yl)ethyl)oxy)phenyl)isoxazol-3-ol sodium salt

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol

3: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.5 h / 20 °C

4: Chiral Pack AD-H column / Resolution of racemate

5: hydrogenchloride / methanol / 2 h / 20 °C

6: sodium hydroxide / water

With hydrogenchloride; hydrogen; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; toluene; 3: Mitsunobu reaction;