2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Base Information

Chemical Name:2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole
CAS No.:187975-06-0
Molecular Formula:C₁₃H₁₅NOS
Molecular Weight:233.334
Hs Code.:

Synonyms:2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Suppliers and Price of 2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

There total 4 articles about 2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 169899-58-5
2-(1-hydroxy-1-phenylmethyl)-4,5-dimethylthiazole

: 74-88-4
methyl iodide

: 187975-06-0
2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Guidance literature:: 2-(1-hydroxy-1-phenylmethyl)-4,5-dimethylthiazole; With sodium hydride; In tetrahydrofuran; at -50 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -50 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1002/anie.201204524

Reference yield:

: 3581-91-7
4,5-Dimethylthiazole

: 187975-06-0
2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 41 percent / tetrahydrofuran / 1.25 h / -78 - 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 83 percent / tetrahydrofuran / 3.5 h / 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; 1.1: Metallation / 1.2: Addition / 2.1: Metallation / 2.2: Methylation;
DOI:10.1021/ja9633528

Reference yield:

: 100-52-7
benzaldehyde

: 187975-06-0
2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C

1.2: 41 percent / tetrahydrofuran / 1.25 h / -78 - 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 83 percent / tetrahydrofuran / 3.5 h / 20 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; 1.1: Metallation / 1.2: Addition / 2.1: Metallation / 2.2: Methylation;
DOI:10.1021/ja9633528