Methyl 3-hydroxyquinoline-4-carboxylate

Base Information

• Chemical Name: Methyl 3-hydroxyquinoline-4-carboxylate
• CAS No.: 73776-18-8
• Molecular Formula: C₁₁H₉NO₃
• Molecular Weight: 203.197
• European Community (EC) Number: 833-528-2
• DSSTox Substance ID: DTXSID90502346
• Wikidata: Q82355283
• Mol file: 73776-18-8.mol

Synonyms:METHYL 3-HYDROXYQUINOLINE-4-CARBOXYLATE;73776-18-8;3-HYDROXY-4-QUINOLINECARBOXYLIC ACID METHYL ESTER;Methyl 3-hydroxycinchoninate;SCHEMBL3159333;DTXSID90502346;NHVBBJBFKMAMEH-UHFFFAOYSA-N;AKOS022647411;AB55614;CS-0238502;METHYL3-HYDROXYQUINOLINE-4-CARBOXYLATE;EN300-196433;3-HYDROXYQUINOLINE-4-CARBOXYLIC ACID METHYL ESTER;Z1410903600

Chemical Property of Methyl 3-hydroxyquinoline-4-carboxylate

Chemical Property:

• PSA: 59.42000
• LogP: 1.72700
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 203.058243149
• Heavy Atom Count: 15
• Complexity: 244

Purity/Quality:

97% ^*data from raw suppliers

methyl3-hydroxyquinoline-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1=C(C=NC2=CC=CC=C21)O

Technology Process of Methyl 3-hydroxyquinoline-4-carboxylate

There total 3 articles about Methyl 3-hydroxyquinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

methanol (67-56-1) + 3-hydroxyquinoline-4-carboxylic acid (118-13-8) → methyl 3-hydroxyquinoline-4-carboxylate (73776-18-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 40h;

Reference yield:

3-hydroxyquinoline-4-carboxylic acid (118-13-8) → methyl 3-hydroxyquinoline-4-carboxylate (73776-18-8)

Guidance literature:

With methanol; sulfuric acid;

DOI:10.1021/jo01133a011

Reference yield:

→ methyl 3-hydroxyquinoline-4-carboxylate (73776-18-8)

Guidance literature:

3-Ethoxycarbonyl-4-methoxycarbonyl-chinolin, wss.-methanol. NaOH;

DOI:10.1002/hlca.19610440305

upstream raw materials:

3-hydroxyquinoline-4-carboxylic acid

methanol