7-benzyloxy-6-bromochromone

Base Information

• Chemical Name: 7-benzyloxy-6-bromochromone
• CAS No.: 1313728-50-5
• Molecular Formula: C₁₆H₁₁BrO₃
• Molecular Weight: 331.166
• Mol file: 1313728-50-5.mol

Synonyms:7-benzyloxy-6-bromochromone

Chemical Property of 7-benzyloxy-6-bromochromone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-benzyloxy-6-bromochromone

There total 8 articles about 7-benzyloxy-6-bromochromone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

7-benzyloxy-6-bromo-2-hydroxychroman-4-one (1313728-51-6) → 7-benzyloxy-6-bromochromone (1313728-50-5)

Guidance literature:

With Amberlyst-15 (H⁺) resin; In isopropyl alcohol; Heating;

DOI:10.1071/CH10296

Reference yield: 49.0%

6-bromo-7-hydroxychromone (1313728-42-5) + benzyl bromide (100-39-0) → 7-benzyloxy-6-bromochromone (1313728-50-5)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; Heating; Reflux;

DOI:10.1071/CH10296

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → 7-benzyloxy-6-bromochromone (1313728-50-5)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine; acetic acid / 0.17 h / 20 °C

2: potassium carbonate; potassium iodide / acetone / 1.83 h / Heating

3: sodium hydride / tetrahydrofuran; hexane / 0.33 h

4: Amberlyst-15 (H⁺) resin / isopropyl alcohol / Heating

With bromine; sodium hydride; potassium carbonate; acetic acid; potassium iodide; In tetrahydrofuran; hexane; isopropyl alcohol; acetone;

DOI:10.1071/CH10296

upstream raw materials:

styrene

2',4'-dihydroxy-4-acetophenone

6-bromo-7-hydroxychromone

benzyl bromide

Downstream raw materials:

(E)-7-benzyloxy-6-styrylchromone

(E)-3-(7-benzyloxy-4-oxo-4H-1-benzopyran-6-yl)-2-propenal

ethyl 3-(7-benzyloxy-4-oxo-4H-1-benzopyran-6-yl)propanoate

(Z)-3-(7-benzyloxy-4-oxo-4H-1-benzopyran-6-yl)acrylonitrile

Refernces