4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester

Base Information

• Chemical Name: 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester
• CAS No.: 1219693-41-0
• Molecular Formula: C₂₀H₂₁NO₅S
• Molecular Weight: 387.456
• Mol file: 1219693-41-0.mol

Synonyms:4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester

Chemical Property of 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester

There total 1 articles about 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-(4-methoxy-phenyl)-4-oxo-crotonic acid ethyl ester (127427-28-5,39644-74-1) + toluene-4-sulfonamide (70-55-3) → 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester (1219693-41-0)

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1039/c0cc04839a

Reference yield:

phenylethylketene (20452-67-9) + 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester (1219693-41-0) → 3-ethyl-6-(4-methoxyphenyl)-2-oxo-3-phenyl-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine-4-carboxylic acid ethyl ester

Guidance literature:

phenylethylketene; 4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester; With 2,5,6,7-tetrahydro-2-phenyl-3H-pyrrolo[2,1-c]-1,2,4-triazol-3-ylidenium chloride; caesium carbonate; In benzene; at 20 ℃; Inert atmosphere;

In 1,2-dimethoxyethane; benzene; at 20 ℃; Inert atmosphere;

DOI:10.1039/c0cc04839a

Reference yield:

4-(4-methoxyphenyl)-4-(toluene-4-sulfonylimino)but-2-enoic acid ethyl ester (1219693-41-0) + 2-chloro-3-phenyl-propionaldehyde (19261-37-1) → ethyl-3-benzyl-6-(4-methoxyphenyl)-2-oxo-1-tosyl-1,2,3,4-tetrahydropyridine-4-carboxylate

Guidance literature:

With 2,5,6,7-tetrahydro-2-phenyl-3H-pyrrolo[2,1-c]-1,2,4-triazol-3-ylidenium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c2cc35273g

upstream raw materials:

4-(4-methoxy-phenyl)-4-oxo-crotonic acid ethyl ester

toluene-4-sulfonamide

Downstream raw materials:

3-ethyl-6-(4-methoxyphenyl)-2-oxo-3-phenyl-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine-4-carboxylic acid ethyl ester

(3S,4S)-ethyl-3-benzyl-6-(4-methoxyphenyl)-2-oxo-1-tosyl-1,2,3,4-tetrahydropyridine-4-carboxylate