benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

Base Information

Chemical Name:benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate
CAS No.:1310817-05-0
Molecular Formula:C₁₉H₂₀N₂O₂S
Molecular Weight:340.446
Hs Code.:

Synonyms:benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

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Chemical Property of benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

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Technology Process of benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

There total 6 articles about benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1310816-98-8
benzyl N-[(3R)-2-thioxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate

: 74-88-4
methyl iodide

: 1310817-05-0
benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

Guidance literature:: benzyl N-[(3R)-2-thioxo-1,3,4,5-tetrahydro-1-benzazepin-3-yl]carbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

Reference yield:

: 145485-03-6
((R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamic acid tert-butyl ester

: 1310817-05-0
benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / methanol / 1 h

2.1: sodium carbonate / water; acetonitrile / 4 h / 20 °C

3.1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C

With Lawessons reagent; hydrogenchloride; water; sodium hydride; sodium carbonate; In tetrahydrofuran; methanol; water; acetonitrile; mineral oil;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1310817-05-0
benzyl N-[(3R)-2-methylsulfanyl-4,5-dihydro-3H-1-benzazepin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / water; acetonitrile / 4 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C

With Lawessons reagent; sodium hydride; sodium carbonate; In tetrahydrofuran; water; acetonitrile; mineral oil;