1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol

Base Information

• Chemical Name: 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol
• CAS No.: 888959-47-5
• Molecular Formula: C₂₈H₄₉NO₇Si
• Molecular Weight: 539.785

Synonyms:1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol

Chemical Property of 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol

There total 3 articles about 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-O-[6-(N-Boc-amino)-hexanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol (709675-82-1) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol (888959-47-5)

Guidance literature:

With 1H-imidazole; at 20 ℃; for 18h;

DOI:10.1021/ol060414i

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol (888959-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / DCC; DMAP / CH₂Cl₂ / 4 °C

2: 90 percent / imidazole / 18 h / 20 °C

With 1H-imidazole; dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/ol060414i

Reference yield:

(R)-3-(4-methoxybenzyloxy)propane-1,2-diol (109786-74-5) → 1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-3-O-(4-methoxybenzyl)-sn-glycerol (888959-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / DCC; DMAP / CH₂Cl₂ / 4 °C

2: 90 percent / imidazole / 18 h / 20 °C

With 1H-imidazole; dmap; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/ol060414i

upstream raw materials:

1-O-[6-(N-Boc-amino)-hexanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol

tert-butyldimethylsilyl chloride

6-(tert-butoxycarbonylamino)hexanoic acid

(R)-3-(4-methoxybenzyloxy)propane-1,2-diol

Downstream raw materials:

6-tert-butoxycarbonylamino-hexanoic acid 2-(tert-butyl-dimethyl-silanyloxy)-3-{[2-(3-{2-[2-(2-{2-[4-(4-dimethylamino-phenylazo)-benzoylamino]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-propionylamino)-ethoxy]-hydroxy-phosphoryloxy}-propyl ester

6-tert-butoxycarbonylamino-hexanoic acid 3-O-({2-[3-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propyonylamino]-ethoxy}-benzyloxy-phosphoryloxy)-2-O-(tert-butyl-dimethylsilyl)-sn-glyceryl ester

benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

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