benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

Base Information

Chemical Name:benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine
CAS No.:888959-50-0
Molecular Formula:C₃₃H₆₁N₂O₇PSi
Molecular Weight:656.916
Hs Code.:

Synonyms:benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

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Chemical Property of benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

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Technology Process of benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

There total 4 articles about benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 888959-48-6
1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glycerol

: 108549-21-9
benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

: 888959-50-0
benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

Guidance literature:: With 1H-tetrazole; In dichloromethane; cooling;
DOI:10.1021/ol060414i

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 888959-50-0
benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

Guidance literature:: Multi-step reaction with 4 steps

1: 49 percent / DCC; DMAP / CH₂Cl₂ / 4 °C

2: 90 percent / imidazole / 18 h / 20 °C

3: 97 percent / DDQ; water / CH₂Cl₂ / 20 °C

4: 85 percent / 1H-tetrazole / CH₂Cl₂ / cooling

With 1H-imidazole; 1H-tetrazole; dmap; water; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1021/ol060414i

Reference yield:

: 709675-82-1
1-O-[6-(N-Boc-amino)-hexanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol

: 888959-50-0
benzyloxy (3-[1-O-[6-(N-Boc-amino)hexanoyl]-2-O-tert-butyldimethylsilyl-sn-glyceryl])(N,N-diisopropylamino)phosphine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / imidazole / 18 h / 20 °C

2: 97 percent / DDQ; water / CH₂Cl₂ / 20 °C

3: 85 percent / 1H-tetrazole / CH₂Cl₂ / cooling

With 1H-imidazole; 1H-tetrazole; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1021/ol060414i