(3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE

Base Information

• Chemical Name: (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE
• CAS No.: 79130-51-1
• Molecular Formula: C11H16ClN
• Molecular Weight: 197.708
• Mol file: 79130-51-1.mol

Synonyms:N,N-Dimethyl-3-phenyl-3-chloropropylamine;

Chemical Property of (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE

Chemical Property:

• Melting Point: 176 °C
• Boiling Point: 261.7±33.0 °C(Predicted)
• PKA: 9.16±0.28(Predicted)
• PSA: 3.24000
• Density: 1.034±0.06 g/cm3(Predicted)
• LogP: 2.91820

Purity/Quality:

98% ^*data from raw suppliers

(3-Chloro-3-phenyl-propyl)-dimethyl-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE

There total 4 articles about (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N,N-dimethyl-3-hydroxy-3-phenylpropylamine (5554-64-3) → 3-chloro-N,N-dimethyl-3-phenylpropan-1-amine (79130-51-1)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

3-dimethylaminopropiophenone (3506-36-3) → 3-chloro-N,N-dimethyl-3-phenylpropan-1-amine (79130-51-1)

Guidance literature:

3-dimethylaminopropiophenone; With sodium tetrahydroborate; In methanol; water; at 20 ℃; for 16h;

With thionyl chloride; In methanol; dichloromethane; water; for 4h; Reflux;

DOI:10.1007/s00702-018-1923-z

Reference yield:

acetophenone (98-86-2) → 3-chloro-N,N-dimethyl-3-phenylpropan-1-amine (79130-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethanol / 2.5 h / Reflux

2.1: sodium tetrahydroborate / methanol; water / 16 h / 20 °C

2.2: 4 h / Reflux

With sodium tetrahydroborate; In methanol; ethanol; water; 1.1: |Mannich Aminomethylation;

DOI:10.1007/s00702-018-1923-z

upstream raw materials:

N,N-dimethyl-3-hydroxy-3-phenylpropylamine

acetophenone

3-dimethylaminopropiophenone

Downstream raw materials:

Dimethyl-[3-(naphthalen-1-ylsulfanyl)-3-phenyl-propyl]-amine

N,N-dimethyl-3-(2-methoxyphenylthio)-3-phenylpropylamine

Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine

N,N-dimethyl-3-(2-methyl-phenyloxy)-3-phenyl-propanamine

Refernces

• 1、 -. "SUBSTITUTED 3-HETEROARYLOXY-3-(HETERO)ARYL-PROPYLAMINES AS SEROTONIN TRANSPORTER AND SEROTONIN HT2C RECEPTOR MODULATORS". Page/Page column 21; 36. . Retrieved 2014/04/04.