(4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

Base Information

Chemical Name:(4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane
CAS No.:537036-24-1
Molecular Formula:C₃₇H₆₀O₇SSi₂
Molecular Weight:705.116
Hs Code.:

Synonyms:(4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

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Technology Process of (4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

There total 3 articles about (4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (2S,3R)-2-(2-benzyloxyethyl)-2-methyl-3-(toluene-4-sulfonyl)oxirane

: 254442-52-9
Trifluoro-methanesulfonic acid (4R,5S)-2,2-di-tert-butyl-5-triethylsilanyloxy-[1,3,2]dioxasilinan-4-ylmethyl ester

: 537036-24-1
(4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -100 ℃;
DOI:10.1016/S0040-4039(03)00252-1

Reference yield:

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 537036-24-1
(4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 95 percent / CH₂Cl₂

2.1: 85 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -100 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4039(03)00252-1

Reference yield:

: 391235-55-5
(4R,5S)-2,2-di-tert-butyl-5-hydroxy-1,3-dioxa-2-silacyclohexane-4-methanol

: 537036-24-1
(4R,5S)-4-[(2S,3R)-3-(2-benzyloxyethyl)-3-methyl-2-(toluene-4-sulfonyl)oxiranylmethyl]-2,2-di-tert-butyl-5-(triethylsilyloxy)-[1,3,2]dioxasilinane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 95 percent / CH₂Cl₂

2.1: 85 percent / n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -100 °C

With 2,6-dimethylpyridine; n-butyllithium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1016/S0040-4039(03)00252-1