allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate

Base Information

• Chemical Name: allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate
• CAS No.: 1416958-90-1
• Molecular Formula: C₂₃H₂₄N₂O₄
• Molecular Weight: 392.455
• Mol file: 1416958-90-1.mol

Synonyms:allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate

Chemical Property of allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate

There total 8 articles about allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

allyl cyanoformate (63934-48-5) + C19H20N2O2 → allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate (1416958-90-1)

Guidance literature:

C₁₉H₂₀N₂O₂; With potassium hexamethylsilazane; In tetrahydrofuran; at -78 ℃; for 6.5h; Inert atmosphere;

allyl cyanoformate; In tetrahydrofuran; at -78 ℃; for 2.5h; Inert atmosphere;

DOI:10.1002/anie.201408609

Reference yield: 35.0%

allyl 4-benzoyl-1-benzyl-3-oxopiperazine-2-carboxylate + methyl iodide (74-88-4) → allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate (1416958-90-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 23 ℃; for 10.5h; Inert atmosphere;

DOI:10.1002/anie.201408609

Reference yield:

4-benzyl-piperazin-2-one (13754-41-1) → allyl 4-benzoyl-1-benzyl-2-methyl-3-oxopiperazine-2-carboxylate (1416958-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - 60 °C / Inert atmosphere

1.2: 4 h / -78 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / -78 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 10.5 h / 23 °C / Inert atmosphere

With caesium carbonate; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/anie.201408609

upstream raw materials:

4-benzyl-piperazin-2-one

methyl iodide

benzoyl chloride

allyl cyanoformate

Downstream raw materials:

(S)-3-allyl-1-benzoyl-4-benzyl-3-methylpiperazin-2-one

Refernces