2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

Base Information

Chemical Name:2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde
CAS No.:1612853-69-6
Molecular Formula:C₂₀H₂₀ClNO₂
Molecular Weight:341.837
Hs Code.:

Synonyms:2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

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Chemical Property of 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

Chemical Property:

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Technology Process of 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

There total 1 articles about 2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.8%

: 1178884-68-8
6-(tert-butyl)-3,4-dihydroisoquinolin-1(2H)-one

: 64622-16-8
2-bromo-6-chlorobenzaldehyde

: 1612853-69-6
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

Guidance literature:: With palladium diacetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In N,N-dimethyl-formamide; at 90 ℃; for 16.5h; Reagent/catalyst; Solvent; Temperature; Time; Inert atmosphere;

Reference yield:

: 1612853-69-6
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

: 1462328-88-6
6-tert-butyl-2-(3-chloro-2-hydroxymethylphenyl)-3,4-dihydro-2H-isoquinolin-1-one

Guidance literature:: With sodium tetrahydroborate; isopropyl alcohol; In dichloromethane; at 2 - 9 ℃; for 1.25h; Solvent; Reagent/catalyst; Temperature; Time;

Reference yield:

: 1612853-69-6
2-(6-tert-butyl-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)-6-chlorobenzaldehyde

: 1418128-76-3
acetic acid 2-(6-tert-butyl-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; isopropyl alcohol / dichloromethane / 1.25 h / 2 - 9 °C

2: pyridine / dichloromethane

3: palladium diacetate; potassium acetate; XPhos / 1,4-dioxane / 75 °C / Inert atmosphere

With pyridine; sodium tetrahydroborate; potassium acetate; palladium diacetate; isopropyl alcohol; XPhos; In 1,4-dioxane; dichloromethane;