1H-Pyrrole-2-carboxylicacid,3-hydroxy-,methylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylicacid,3-hydroxy-,methylester(9CI)
• CAS No.: 79068-31-8
• Molecular Formula: C6H7 N O3
• Molecular Weight: 141.126
• Hs Code.: 2933990090
• Mol file: 79068-31-8.mol

Synonyms:1H-Pyrrole-2-carboxylicacid,3-hydroxy-,methylester(9CI);Methyl 3-hydroxy-1-H-pyrrole-2-carboxyate;1H-Pyrrole-2-carboxylic acid, 3-hydroxy-, Methyl ester;3-Hydroxy-2-pyrrolcarbonsaeure-Methylester;3-hydroxy-1H-pyrrole-2-carboxylic acid Methyl ester

Chemical Property of 1H-Pyrrole-2-carboxylicacid,3-hydroxy-,methylester(9CI)

Chemical Property:

• Boiling Point: 264.202°C at 760 mmHg (Cal.)
• Flash Point: 113.585°C (Cal.)
• PSA: 62.32000
• Density: 1.356g/cm3 (Cal.)
• LogP: 0.50690
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-hydroxy-1H-pyrrole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxylicacid,3-hydroxy-,methylester(9CI)

There total 1 articles about 1H-Pyrrole-2-carboxylicacid,3-hydroxy-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

methyl-Δ1-pyrroline-2-carboxylate (57224-14-3) + diethylazodicarboxylate (1972-28-7,218603-74-8) → methyl Pyrrole-2-carboxylate (1193-62-0) + methyl 3-hydroxy-1H-pyrrol-2-yl-carboxylate (79068-31-8) + 3-<1,2-Bis(ethoxycarbonyl)hydrazinol>-1-pyrrolin-2-carbonsaeure-methylester (79068-33-0) + 3-<1,2-Bis(ethoxycarbonyl)hydrazino>-2-pyrrolcarbonsaeure-methylester (79068-30-7)

Guidance literature:

In benzene; at 80 ℃; for 9h; Further byproducts given;

Reference yield:

methyl 3-hydroxy-1H-pyrrol-2-yl-carboxylate (79068-31-8) + p-toluenesulfonyl chloride (98-59-9) → methyl 3-(tosyloxy)-1H-pyrrole-2-carboxylate (874144-74-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

upstream raw materials:

methyl-Δ¹-pyrroline-2-carboxylate

diethylazodicarboxylate

Downstream raw materials:

methyl 3-(tosyloxy)-1H-pyrrole-2-carboxylate