2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate

Base Information

• Chemical Name: 2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate
• CAS No.: 1032678-20-8
• Molecular Formula: C₃₈H₅₀N₃O₂*F₆P
• Molecular Weight: 725.798
• Mol file: 1032678-20-8.mol

Synonyms:2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate

Chemical Property of 2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate

There total 1 articles about 2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-[5-(1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-(5-carboxypentyl)-3H-indolium chloride (1032678-07-1) + trans-4-aminocyclohexanol hydrochloride (50910-54-8) → 2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate (1032678-20-8)

Guidance literature:

2-[5-(1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-(5-carboxypentyl)-3H-indolium chloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

trans-4-aminocyclohexanol hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1002/ejoc.200701190

Reference yield: 93.0%

2-[5-(1,3,3-trimethyl-2,3-dihydroindol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-[5-(trans-4-hydroxycyclohexylaminocarbonyl)pentyl]-3H-indolium hexafluorophosphate (1032678-20-8) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 2-[5-(1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-{5-[trans-4-(diisopropylamino-2-cyanoethoxyphosphanyloxy)cyclohexylaminocarbonyl]pentyl}-3H-indolium hexafluorophosphate

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.200701190

upstream raw materials:

2-[5-(1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene)-1,3-pentadienyl]-3,3-dimethyl-1-(5-carboxypentyl)-3H-indolium chloride

trans-4-aminocyclohexanol hydrochloride

Refernces