5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid

Base Information

• Chemical Name: 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid
• CAS No.: 129650-08-4
• Molecular Formula: C₁₅H₂₀O₃
• Molecular Weight: 248.322
• Mol file: 129650-08-4.mol

Synonyms:5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid

Chemical Property of 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid

There total 4 articles about 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-(4-methoxyphenyl)-3,3-tetramethylenepentanoic acid (129650-07-3) → 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid (129650-08-4)

Guidance literature:

With hydrogen bromide; In acetic acid; for 2.5h; Heating;

DOI:10.1021/jm00172a024

Reference yield:

3,3-tetramethylene glutaric anhydride (5662-95-3) → 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid (129650-08-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / AlCl₃ / nitrobenzene; various solvent(s) / 2 h

2: 96 percent / H₂ / 10percent Pd/C / acetic acid / 1.5 h / 2327.2 Torr

3: 72 percent / 47-59percent aq. HBr / acetic acid / 2.5 h / Heating

With aluminium trichloride; hydrogen bromide; hydrogen; palladium on activated charcoal; In acetic acid; nitrobenzene;

DOI:10.1021/jm00172a024

Reference yield:

5-(4-methoxyphenyl)-5-oxo-3,3-tetramethylenepentanoic acid (403481-48-1) → 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid (129650-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂ / 10percent Pd/C / acetic acid / 1.5 h / 2327.2 Torr

2: 72 percent / 47-59percent aq. HBr / acetic acid / 2.5 h / Heating

With hydrogen bromide; hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1021/jm00172a024

upstream raw materials:

5-(4-methoxyphenyl)-3,3-tetramethylenepentanoic acid

3,3-tetramethylene glutaric anhydride

5-(4-methoxyphenyl)-5-oxo-3,3-tetramethylenepentanoic acid

methoxybenzene

Downstream raw materials:

2-(4-{2-[1-(1H-Tetrazol-5-ylmethyl)-cyclopentyl]-ethyl}-phenoxymethyl)-quinoline

(1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester

2-(1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetamide

5-[4-(quinolin-2-ylmethoxy)phenyl]-3,3-tetramethylenepentanoic acid