(1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester

Base Information

• Chemical Name: (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester
• CAS No.: 129650-09-5
• Molecular Formula: C₂₆H₂₉NO₃
• Molecular Weight: 403.521
• Mol file: 129650-09-5.mol

Synonyms:(1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester

Chemical Property of (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester

There total 6 articles about (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

2-Chloromethylquinoline (4377-41-7) + methyl 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoate (129650-06-2) → (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester (129650-09-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; for 72h; Heating;

DOI:10.1021/jm00172a024

Reference yield:

3,3-tetramethylene glutaric anhydride (5662-95-3) → (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester (129650-09-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / AlCl₃ / nitrobenzene; various solvent(s) / 2 h

2: 96 percent / H₂ / 10percent Pd/C / acetic acid / 1.5 h / 2327.2 Torr

3: 72 percent / 47-59percent aq. HBr / acetic acid / 2.5 h / Heating

4: 90 percent / concd. H₂SO₄ / 2 h / Heating

5: 44 percent / K₂CO₃ / acetone; dimethylformamide / 72 h / Heating

With aluminium trichloride; sulfuric acid; hydrogen bromide; hydrogen; potassium carbonate; palladium on activated charcoal; In acetic acid; nitrobenzene; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm00172a024

Reference yield:

5-(4-methoxyphenyl)-5-oxo-3,3-tetramethylenepentanoic acid (403481-48-1) → (1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetic acid methyl ester (129650-09-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / H₂ / 10percent Pd/C / acetic acid / 1.5 h / 2327.2 Torr

2: 72 percent / 47-59percent aq. HBr / acetic acid / 2.5 h / Heating

3: 90 percent / concd. H₂SO₄ / 2 h / Heating

4: 44 percent / K₂CO₃ / acetone; dimethylformamide / 72 h / Heating

With sulfuric acid; hydrogen bromide; hydrogen; potassium carbonate; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jm00172a024

upstream raw materials:

2-Chloromethylquinoline

methyl 5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoate

3,3-tetramethylene glutaric anhydride

5-(4-hydroxyphenyl)-3,3-tetramethylenepentanoic acid

Downstream raw materials:

5-[4-(quinolin-2-ylmethoxy)phenyl]-3,3-tetramethylenepentanoic acid

5-<4-(quinolin-2-ylmethoxy)phenyl>-3,3-tetramethylenepentanenitrile

2-(1-{2-[4-(Quinolin-2-ylmethoxy)-phenyl]-ethyl}-cyclopentyl)-acetamide

2-(4-{2-[1-(1H-Tetrazol-5-ylmethyl)-cyclopentyl]-ethyl}-phenoxymethyl)-quinoline