5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole

Base Information

• Chemical Name: 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole
• CAS No.: 188538-67-2
• Molecular Formula: C₁₆H₁₃Cl₂F₃N₄Si
• Molecular Weight: 417.293
• Mol file: 188538-67-2.mol

Synonyms:5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole

Chemical Property of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole

There total 4 articles about 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-iodo-1H-pyrazole-3-carbonitrile (188539-59-5) → 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole (188538-67-2)

Guidance literature:

Reference yield:

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (120068-79-3) → 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole (188538-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1: N-iodo-succinimide

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; 2: |Sonogashira Cross-Coupling;

DOI:10.1016/j.envint.2017.03.012

Reference yield:

trimethylsilylacetylene (1066-54-2) + 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-iodo-1H-pyrazole-3-carbonitrile (188539-59-5) → 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole (188538-67-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;

DOI:10.1016/j.envint.2017.03.012

upstream raw materials:

5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-iodo-1H-pyrazole-3-carbonitrile

5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole

trimethylsilylacetylene

Downstream raw materials:

5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethynylpyrazole

4-Acetyl-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole