(+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

Base Information

Chemical Name:(+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one
CAS No.:1449522-88-6
Molecular Formula:C₃₅H₄₀O₇
Molecular Weight:572.698
Hs Code.:

Synonyms:(+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

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Chemical Property of (+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

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Technology Process of (+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

There total 7 articles about (+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1449522-87-5
(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

: 1449522-88-6
(+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

Guidance literature:: With palladium(II) acetylacetonate; 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene; caesium carbonate; silver(I) iodide; In 1,4-dioxane; at 120 ℃; for 42h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.07.038

Reference yield:

: 1449522-85-3
(-)-2-bromo-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

: 1449522-88-6
(+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(II) oxide; copper(I) oxide / pyridine / 22 h / 120 °C / Inert atmosphere

2: copper(l) iodide; sodium iodide; N,N-dimethylethylenediamine / 1,4-dioxane / 42 h / 120 °C / Inert atmosphere

3: 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene; caesium carbonate; palladium(II) acetylacetonate; silver(I) iodide / 1,4-dioxane / 42 h / 120 °C / Inert atmosphere

With copper(I) oxide; palladium(II) acetylacetonate; copper(l) iodide; 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene; potassium carbonate; caesium carbonate; N,N-dimethylethylenediamine; sodium iodide; silver(I) iodide; copper(II) oxide; In 1,4-dioxane; pyridine; 1: |Ullmann Condensation / 3: |Heck Reaction;
DOI:10.1016/j.tetlet.2013.07.038

Reference yield:

: 1449522-86-4
(-)-2-(5-bromo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

: 1449522-88-6
(+)-(14R,15S,E)-14-(4-methoxybenzyloxy)-1,11,11-trimethyl-15-pentyl-14,15-dihydro-5H-benzo[b]-10,12-dioxo[1,2-j][1,5]dioxacycloundecin-17(9H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; sodium iodide; N,N-dimethylethylenediamine / 1,4-dioxane / 42 h / 120 °C / Inert atmosphere

2: 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene; caesium carbonate; palladium(II) acetylacetonate; silver(I) iodide / 1,4-dioxane / 42 h / 120 °C / Inert atmosphere

With palladium(II) acetylacetonate; copper(l) iodide; 1,4-bis(4'-methoxyphenyl)-1,4-diazabuta-1,3-diene; caesium carbonate; N,N-dimethylethylenediamine; sodium iodide; silver(I) iodide; In 1,4-dioxane; 2: |Heck Reaction;
DOI:10.1016/j.tetlet.2013.07.038