(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

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Chemical Name:(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester
CAS No.:1449522-87-5
Molecular Formula:C₃₅H₄₁IO₇
Molecular Weight:700.611
Hs Code.:

Synonyms:(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

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Chemical Property of (-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

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Technology Process of (-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

There total 6 articles about (-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1449522-86-4
(-)-2-(5-bromo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

: 1449522-87-5
(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

Guidance literature:: With copper(l) iodide; N,N-dimethylethylenediamine; sodium iodide; In 1,4-dioxane; at 120 ℃; for 42h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.07.038

Reference yield:

: 66-25-1
hexanal

: 1449522-87-5
(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: [(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole][4-cyano-3-nitrobenzenecarboxylato] [1,2,3-eta-2-propenyl Ir(III)]; potassium phosphate / tetrahydrofuran; isopropyl alcohol / 52 h / 60 °C / Inert atmosphere

2: sodium hydride / dichloromethane; tetrahydrofuran; mineral oil / 2.5 h / Inert atmosphere; Reflux

3: potassium carbonate / methanol / 18 h / 20 - 50 °C / Inert atmosphere

4: potassium hexamethylsilazane; triethylamine / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C / Inert atmosphere

5: potassium carbonate; copper(II) oxide; copper(I) oxide / pyridine / 22 h / 120 °C / Inert atmosphere

6: copper(l) iodide; sodium iodide; N,N-dimethylethylenediamine / 1,4-dioxane / 42 h / 120 °C / Inert atmosphere

With copper(I) oxide; potassium phosphate; copper(l) iodide; [(R)-(+)-5,5'-bis(diphenylphosphino)-4,4'-bi-1,3-benzodioxole][4-cyano-3-nitrobenzenecarboxylato] [1,2,3-eta-2-propenyl Ir(III)]; potassium hexamethylsilazane; sodium hydride; potassium carbonate; N,N-dimethylethylenediamine; triethylamine; sodium iodide; copper(II) oxide; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; isopropyl alcohol; toluene; mineral oil; 5: |Ullmann Condensation;
DOI:10.1016/j.tetlet.2013.07.038

Reference yield:

: 1449522-84-2
2-bromo-6-methylbenzoic acid (S)-1-[(R)-1-hydroxyallyl]hexyl ester

: 1449522-87-5
(-)-2-(5-iodo-2,2-dimethyl-4H-benzo[1,3]dioxin-6-yloxy)-6-methylbenzoic acid (S)-1-[(R)-1-(4-methoxybenzyloxy)allyl]hexyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hexamethylsilazane; triethylamine / tetrahydrofuran; toluene / 1.5 h / -78 - 20 °C / Inert atmosphere

2: potassium carbonate; copper(II) oxide; copper(I) oxide / pyridine / 22 h / 120 °C / Inert atmosphere

3: copper(l) iodide; sodium iodide; N,N-dimethylethylenediamine / 1,4-dioxane / 42 h / 120 °C / Inert atmosphere

With copper(I) oxide; copper(l) iodide; potassium hexamethylsilazane; potassium carbonate; N,N-dimethylethylenediamine; triethylamine; sodium iodide; copper(II) oxide; In tetrahydrofuran; 1,4-dioxane; pyridine; toluene; 2: |Ullmann Condensation;
DOI:10.1016/j.tetlet.2013.07.038