N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

Base Information

Chemical Name:N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide
CAS No.:340963-53-3
Molecular Formula:C₃₇H₄₂N₂O₆Si
Molecular Weight:638.836
Hs Code.:

<i>N</i>-[1-(3-acetylamino-2-methoxy-phenyl)-2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-ethyl]-<i>N</i>-(4-methoxy-benzyl)-2-oxo-acetamide

Synonyms:N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

There total 13 articles about N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 340963-51-1
(R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide

: 340963-53-3
N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -50 - 20 ℃;
DOI:10.1021/jo015512q

Reference yield:

: 82807-38-3
1-(2-methoxyphenyl)ethane-1,2-diol

: 340963-53-3
N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 12 steps

1: 94 percent / pyridine / 8 h / 20 °C

2: 83 percent / KNO₃; TFAA / CHCl₃ / 48 h / 0 °C

3: 93 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

6: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

7: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

8: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

9: H₂ / 10percent Pd/C / propan-1-ol / 4 h / 760.05 Torr

10: 3.732 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

11: 89 percent / K₂CO₃ / methanol; H₂O / 1.5 h

12: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 20 °C

With 4-methyl-morpholine; 1H-imidazole; oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; dimethyl sulfoxide; potassium nitrate; triethylamine; triphenylphosphine; trifluoroacetic anhydride; diethylazodicarboxylate; isobutyl chloroformate; 10percent Pd/C; In tetrahydrofuran; pyridine; methanol; propan-1-ol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction / 12: Swern oxidation;
DOI:10.1021/jo015512q

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 340963-53-3
N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

4: 84 percent / NaBH₃CN; AcOH / methanol / 0 - 20 °C

5: 74 percent / NMM; isobutyl chloroformate / CH₂Cl₂ / 12 h / 20 °C

6: H₂ / 10percent Pd/C / propan-1-ol / 4 h / 760.05 Torr

7: 3.732 g / Et₃N / CH₂Cl₂ / 12 h / 20 °C

8: 89 percent / K₂CO₃ / methanol; H₂O / 1.5 h

9: 94 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -50 - 20 °C

With 4-methyl-morpholine; 1H-imidazole; oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; hydrazine hydrate; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; 10percent Pd/C; In tetrahydrofuran; methanol; propan-1-ol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Mitsunobu reaction / 9: Swern oxidation;
DOI:10.1021/jo015512q