ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Base Information

Chemical Name:ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate
CAS No.:95250-12-7
Molecular Formula:C₂₁H₁₈Cl₃NO₆
Molecular Weight:486.736
Hs Code.:

Synonyms:ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

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Chemical Property of ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

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Technology Process of ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

There total 5 articles about ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 2832-19-1
2-Chloro-N-(hydroxymethyl)acetamide

: 95249-99-3
ethyl 6,7-dichloro-2,3-dihydro-5-(4-hydroxybenzoyl)-2-benzofurancarboxylate

: 95250-12-7
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Guidance literature:: With sulfuric acid; at 10 - 15 ℃; for 6h;
DOI:10.1021/jm50001a009

Reference yield:

: 90246-58-5
6,7-Dichloro-2,3-dihydro-5-(p-nitrobenzoyl)-benzofuran-2-carboxylic acid

: 95250-12-7
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / acetaldoxime, NaOH / dimethylformamide / Ambient temperature

2: CH₃SO₃H / 16 h / Ambient temperature

3: conc. aq. H₂SO₄ / Ambient temperature

With sodium hydroxide; Acetaldehyde oxime; methanesulfonic acid; sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00378a011

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 95250-12-7
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<(chloroacetamido)methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: AlCl₃ / CH₂Cl₂ / 1 h / 80 - 90 °C

2: 1 N aq. NaOH / ethanol / 60 °C

3: 73 percent / acetaldoxime, NaOH / dimethylformamide / Ambient temperature

4: CH₃SO₃H / 16 h / Ambient temperature

5: conc. aq. H₂SO₄ / Ambient temperature

With sodium hydroxide; aluminium trichloride; Acetaldehyde oxime; methanesulfonic acid; sulfuric acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00378a011