1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide
CAS No.:1359029-94-9
Molecular Formula:C₁₄H₁₄F₃N₃O
Molecular Weight:297.28
Hs Code.:

Synonyms:1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

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Chemical Property of 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

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Technology Process of 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

There total 5 articles about 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359029-69-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid

: 1359029-94-9
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

Guidance literature:: 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylic acid; With oxalyl dichloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere; Cooling with ice;

With ammonium hydroxide; In 1,4-dioxane; at 20 ℃; for 10h; Cooling with ice;

Reference yield:

: 1359029-55-2
ethyl 1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazol-4-carboxylate

: 1359029-94-9
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; ethanol / 3 h / Reflux

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

2.2: 10 h / 20 °C / Cooling with ice

With oxalyl dichloride; ethanol; potassium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 1356997-44-8
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole

: 1359029-94-9
1-methyl-5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-iodo-succinimide; trifluoroacetic acid / 1 h / 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 65 °C

3.1: potassium hydroxide; ethanol / 3 h / Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ice

4.2: 10 h / 20 °C / Cooling with ice

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; ethanol; potassium carbonate; trifluoroacetic acid; potassium hydroxide; In N,N-dimethyl-formamide;