6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil

Base Information

• Chemical Name: 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil
• CAS No.: 638212-21-2
• Molecular Formula: C₁₆H₁₈N₄O₇S
• Molecular Weight: 410.408
• Mol file: 638212-21-2.mol

Synonyms:6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil

Chemical Property of 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil

There total 3 articles about 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-methyl-N-(oxiran-2-ylmethyl)benzenesulfonamide (5997-56-8) + 6-chloro-1,3-dimethyl-5-nitrouracil (1203-25-4) → 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil (638212-21-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.3987/COM-03-9872

Reference yield:

4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) → 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil (638212-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: m-CPBA / CH₂Cl₂ / 24 h / 20 °C

2: 90 percent / NaH / tetrahydrofuran / 1.5 h / 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.3987/COM-03-9872

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 6-[N-(2,3-epoxypropyl)-N-tosyl]amino-5-nitro-1,3-dimethyluracil (638212-21-2)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 30 h / 20 °C

2: m-CPBA / CH₂Cl₂ / 24 h / 20 °C

3: 90 percent / NaH / tetrahydrofuran / 1.5 h / 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.3987/COM-03-9872

upstream raw materials:

4-methyl-N-(oxiran-2-ylmethyl)benzenesulfonamide

6-chloro-1,3-dimethyl-5-nitrouracil

4-methyl-N-(2-propenyl)benzenesulfonamide

p-toluenesulfonyl chloride

Downstream raw materials:

toluene-4-sulfonic acid 1,3-dimethyl-2,4-dioxo-9-(toluene-4-sulfonyl)-2,3,4,5,6,7,8,9-octahydro-1H-pyrimido[4,5-b][1,4]diazepin-7-yl ester

7-hydroxy-1,3-dimethyl-9-(toluene-4-sulfonyl)-1,5,6,7,8,9-hexahydro-pyrimido[4,5-b][1,4]diazepine-2,4-dione

5-amino-6-(N-2,3-epoxypropyl-N-tosyl)amino-1,3-dimethyluracil