6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

Base Information

Chemical Name:6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine
CAS No.:1332703-57-7
Molecular Formula:C₂₇H₁₉F₃N₂O
Molecular Weight:444.456
Hs Code.:

Synonyms:6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

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Technology Process of 6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

There total 9 articles about 6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1332703-54-4
6-bromo-2-phenyl-3-(4-trifluoromethylphenyl)imidazo-[1,2-a]pyridine

: 5720-07-0
4-methoxyphenylboronic acid

: 1332703-57-7
6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 140 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.tet.2011.06.108

Reference yield:

: 1332703-38-4
3-bromo-6-(4-methoxyphenyl)-2-phenylimidazo[1,2-a]pyridine

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1332703-57-7
6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 140 ℃; for 2h; Microwave irradiation;
DOI:10.1016/j.tet.2011.06.108

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1332703-57-7
6-(4-methoxyphenyl)-2-phenyl-3-(4-trifluoromethylphenyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / Reflux

2: N-iodo-succinimide / acetonitrile / 1 h / 20 °C

3: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenyl-arsane; potassium carbonate / 1,4-dioxane; ethanol / 6 h / 50 °C / Inert atmosphere

4: palladium diacetate; potassium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; N-iodo-succinimide; triphenyl-arsane; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetonitrile; 3: Suzuki coupling / 4: Suzuki coupling;
DOI:10.1016/j.tet.2011.06.108