N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Base Information

Chemical Name:N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide
CAS No.:1357587-06-4
Molecular Formula:C₂₆H₂₅F₃N₆O₂S
Molecular Weight:542.585
Hs Code.:

Synonyms:N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

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Chemical Property of N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

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Technology Process of N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

There total 23 articles about N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1357587-06-4
N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5.1: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

7.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / 20 °C

9.1: tosylanhydride / α,α,α-trifluorotoluene / 0 °C

10.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

11.1: sodium cyanoborohydride; acetic acid; methanol / water / 1 h / 20 °C

11.2: 8 h / 60 °C

With pyridine; hydrogenchloride; methanol; N-Bromosuccinimide; sodium cyanoborohydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1357587-06-4
N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

: 1357587-99-5
N-{3-[4-(2-tert-butylaminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 2.17 h / 0 - 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 4 h / 100 °C / Inert atmosphere

4: toluene-4-sulfonic acid / methanol / 1 h / 20 °C

5: N-Bromosuccinimide / dichloromethane / 1.5 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

7: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 100 °C / Inert atmosphere

8: 3-chloro-benzenecarboperoxoic acid / 20 °C

9: tosylanhydride / α,α,α-trifluorotoluene / 0 °C

10: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C / Inert atmosphere

11: sodium cyanoborohydride; acetic acid; methanol / water / 1 h / 20 °C

With pyridine; hydrogenchloride; methanol; N-Bromosuccinimide; sodium cyanoborohydride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1357587-98-4
N-{3-[4-(2-tert-butylaminopyridin-4-yl)-1-piperidin-4-yl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide

: 1357587-06-4
N-{3-[4-(2-aminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide

Guidance literature:: formaldehyd; N-{3-[4-(2-tert-butylaminopyridin-4-yl)-1-piperidin-4-yl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide; With methanol; sodium cyanoborohydride; acetic acid; In water; at 20 ℃; for 1h;

With trifluoroacetic acid; In water; at 60 ℃; for 8h;