(2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Base Information

Chemical Name:(2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
CAS No.:1027942-14-8
Molecular Formula:C₂₂H₃₁NO₆
Molecular Weight:405.491
Hs Code.:

Synonyms:(2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Chemical Property of (2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

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Technology Process of (2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 4 articles about (2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 497065-57-3
(2S,5R,6S)-1-benzyloxycarbonyl-5-methyl-6-(4'-acetoxybutyl)-1,2,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

: 1027942-14-8
(2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: With hydrogen; sodium nitrite; platinum(IV) oxide; In methanol; for 12h;
DOI:10.1021/ja028937i

Reference yield:

: 18545-16-9
5-acetoxypentanal

: 1027942-14-8
(2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: MgSO₄ / CH₂Cl₂ / 0.17 h / -78 °C

1.2: TiCl₄ / CH₂Cl₂ / 12 h / 20 °C

2.1: 242 mg / Na₂CO₃ / CH₂Cl₂ / 4 h / 0 °C

3.1: H₂; NaNO₂ / PtO₂ / methanol / 12 h

With hydrogen; sodium carbonate; magnesium sulfate; sodium nitrite; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/ja028937i

Reference yield:

: 497065-79-9
(E)-(2R,3R)-2-Amino-3-(dimethyl-phenyl-silanyl)-hex-4-enoic acid methyl ester

: 1027942-14-8
(2S,5R,6S)-6-(4-Acetoxy-butyl)-5-methyl-piperidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: MgSO₄ / CH₂Cl₂ / 0.17 h / -78 °C

1.2: TiCl₄ / CH₂Cl₂ / 12 h / 20 °C

2.1: 242 mg / Na₂CO₃ / CH₂Cl₂ / 4 h / 0 °C

3.1: H₂; NaNO₂ / PtO₂ / methanol / 12 h

With hydrogen; sodium carbonate; magnesium sulfate; sodium nitrite; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/ja028937i